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CasNo： 43120-28-1
MF： C9H8N2O2
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1H-Indazole-3-carboxylic acid methyl ester is a member of the indazoles and has the chemical formula C9H8N2O2. It can be synthesized from methanol and 2H-Indazole-3-carboxylic acid. Indazole-3-carboxylic Acid Methyl Ester has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors.
The CAS number of 1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER is 43120-28-1.
More information of 1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER 43120-28-1 are:
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Synonyms |
Indazole-3-carboxylicacid, methyl ester (7CI);3-(Methoxycarbonyl)-1H-indazole;Methyl1H-indazole-3-carboxylate;Methyl 3-indazolecarboxylate; |
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CAS Number |
43120-28-1 |
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Molecular Formula |
C9H8N2O2 |
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Molecular Weight |
176.175 |
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Density |
1.325 g/cm3 |
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Melting Point |
162-163℃ |
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Boiling Point |
345.2 °C at 760 mmHg |
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Flash Point |
162.6 °C |
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HS CODE |
2933990090 |
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PSA |
54.98000 |
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LogP |
1.34950 |
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Pka |
11.93±0.40(Predicted) |
1H-Indazole-3-carboxylic acid methyl ester has several potential uses, including:
Inhibiting human neutrophil elastase
N-benzoylindazole derivatives and analogues of 1H-Indazole-3-carboxylic acid methyl ester may have this potential.
Preparing indazole-pyridine based protein kinase/Akt inhibitors
1H-Indazole-3-carboxylic acid methyl ester can be used in the preparation of these inhibitors.
Cancer therapy
1H-Indazole-3-carboxylic acid methyl ester may have potential use in cancer therapy because it can induce apoptosis.
InChI:InChI=1/C9H8N2O2/c1-13-9(12)8-6-4-2-3-5-7(6)10-11-8/h2-5H,1H3,(H,10,11)
Articles related to 1H-INDAZOLE-3-CARBOXYLIC ACID METHYL ESTER:
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Article |
Source |
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Regioselective N-alkylation of the 1H-indazole scaffold; ring substituent and N-alkylating reagent effects on regioisomeric distribution |
Alam, Ryan M.,Keating, John J. supporting information, p. 1939 - 1951 (2021/08/23) |
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Preparation methods of 1H-indazol-3-carboxylic acid derivative, granisetron and lonidamine |
- Paragraph 0072-0077; 0097-0102; 0122; 0133-0135, (2021/05/12) |
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