M-METHYLPROPIOPHENONE

• Molecular Formula:C10H12O
• Molecular Weight:148.205
• Melting Point:-4.4°C 
• Refractive Index:1.5413 (estimate) 
• Boiling Point:230.3 °C at 760 mmHg 
• Flash Point:98.1 °C 
• PSA：17.07000 
• Density:0.963 g/cm³ 
• LogP:2.58770 

M-Methylpropiophenone, also known as 3'-Methylpropiophenone, is a ketone derived from propiophenone, characterized by the presence of a methyl group at the meta position on the benzene ring. This compound is a pale yellow liquid with a sweet, floral odor and is used as an intermediate in the synthesis of pharmaceuticals and fragrances. Dorne chemical technology co. LTD is a comprehensive chemical enterprise integrating r&d, production and sales. It is a leading manufacturer and supplier of chemical products in China.We develop, produce and market high quality pharmaceuticals, intermediates, specialty chemicals and OLED intermediates, as well as other fine chemicals.Relying on the laboratory and taking the factory as the base, the company has the whole process ability of fine chemical product research and development, production and processing, testing and packaging to export.We have a research team of excellent engineers, professional technical personnel dedicated to the research and development of new products, in addition, we are also committed to industry and academia to provide customized synthetic research services.

51772-30-6 Process route

123-62-6

propionic acid anhydride

108-88-3,15644-74-3,16713-13-6

toluene

2040-14-4

2-methylpropiophenone

5337-93-9

4'-methylpropiophenone

51772-30-6

3'-Methylpropiophenone

Conditions

Conditions	Yield
With indium(III) chloride; 1-butyl-3-methylimidazolium chloride; at 110 ℃; for 48h; Title compound not separated from byproducts;
With chlorosulfonic acid-modified mesoporous zirconia; at 180 ℃; for 3h; Reagent/catalyst; Temperature; Kinetics; Autoclave; Neat (no solvent);

925-90-6

ethylmagnesium bromide

620-22-4

3-Methylbenzonitrile

51772-30-6

3'-Methylpropiophenone

Conditions

Conditions	Yield
ethylmagnesium bromide; 3-Methylbenzonitrile; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; With water; In tetrahydrofuran; Cooling with ice;	94%
In tetrahydrofuran; at 0 - 20 ℃; for 72.5h; Cooling with ice bath; Inert atmosphere;	94%
With copper(l) iodide; In tetrahydrofuran; for 22h; Inert atmosphere;	94%
ethylmagnesium bromide; 3-Methylbenzonitrile; In tetrahydrofuran; at 20 ℃; for 18h; With sulfuric acid; In tetrahydrofuran; at 0 ℃;	67%
With diethyl ether; anschliessend Erwaermen mit wss. HCl;
With diethyl ether; anschliessend Erwaermen mit wss. H2SO4;