What is the ACTH (4-7), Pro-Gly-Pro-?

ACTH (4-7), Pro-Gly-Pro- is , while it's Molecular Formula is C37H51N9O10S.

What is the CAS number for ACTH (4-7), Pro-Gly-Pro-?

The CAS number of ACTH (4-7), Pro-Gly-Pro- is 80714-61-0.

What is ACTH (4-7), Pro-Gly-Pro- (80714-61-0) used for?

Semax is a synthetic analogue of the adrenocorticotropic hormone, a hormone responsible for theproduction of cortisol which in turn regulates glucose and lipid metabolism and helps to maintainblood pressure. In the hippocampus, Semax rapidly elevates the levels of brain-derived neurotrophicfactor (BDNF), a protein important in encouraging growth and differentiation of new neurons andsynapses. BDNF is active in the hippocampus, cortex, and forebrain and is important for memory,coordination, concentration, and learning. Semax also works to activate the dopaminergic andserotonergic systems to help prime the brain for action and to induce a controlled state of mentalstress.InChI:InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26?,27-,28-,29-/m0/s1

ACTH (4-7), Pro-Gly-Pro-

Basic information

Product Name:ACTH (4-7), Pro-Gly-Pro-
CasNo.:80714-61-0
MF:C₃₇H₅₁N₉O₁₀S
MW:813.932

Physical and Chemical Properties

Purity:99%
Boiling Point:
Packing:
Throughput:

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Product Details

CasNo： 80714-61-0

MF： C₃₇H₅₁N₉O₁₀S

Factory Supply High Purity Semax, Top Purity 80714-61-0 In Stock

Molecular Formula:C37H51N9O10S
Molecular Weight:813.932
Vapor Pressure:0mmHg at 25°C
Boiling Point:1335.2°Cat760mmHg
PKA:3.43±0.20(Predicted)
Flash Point:761.3°C
PSA：325.58000
Density:1.391g/cm³
LogP:2.71460

Semax(Cas 80714-61-0) Usage

Description

Semax is a heptapeptide and synthetic analogue of a fragment of adrenocorticotropic hormone (ACTH), ACTH (4-10), of the following amino acid sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP in single-letter form).

Uses

Semax is a synthetic peptide, derived from adrenocorticotropic hormone (ACTH), used primarily for its nootropic and neuroprotective effects. It is known to enhance cognitive functions, such as memory, learning, and attention, making it beneficial in treating various neurological conditions, including stroke, cognitive impairments, and optic nerve diseases. Semax exerts its effects by modulating the activity of the brain-derived neurotrophic factor (BDNF) and stimulating neurogenesis and synaptic plasticity.

InChI:InChI=1/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26?,27-,28-,29-/m0/s1

80714-61-0 Relevant articles

Semax and Pro-Gly-Pro Activate the Transcription of Neurotrophins and Their Receptor Genes after Cerebral Ischemia

Veronika G. Dmitrieva, Oksana V. Povarova, Veronika I. Skvortsova, Svetlana A. Limborska, Nikolai F. Myasoedov & Lyudmila V. Dergunova

, Cellular and Molecular Neurobiology, Volume 30, pages 71–79, (2010)

We have shown for the first time that both Semax and PGP activate the transcription of neurotrophins and their receptors in the cortex of rats subjected to pMCAO. The profiles of transcription alteration under PGP and Semax treatment were partially overlapped.

Experimental substantiation of application of Semax as a modulator of immune reaction on the model of “social” stress

M. A. Samotrueva, A. L. Yasenyavskaya, V. Kh. Murtalieva, O. A. Bashkina, N. F. Myasoedov, L. A. Andreeva & A. V. Karaulov

, Bulletin of Experimental Biology and Medicine, Volume 166, pages 754–758, (2019)

We studied immunocorrecting effects of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) on the model of “social” stress caused by sensory contact and intermale confrontation. Functional activity of the immune system of laboratory animals was evaluated in standard immunopharmacological tests: delayed-type hypersensitivity reaction, direct agglutination test, latex test for studying phagocytic activity of peripheral blood neutrophils, changes in differential leukocyte count, and weight of immunocompetent organs.

80714-61-0 Upstream products

92411-06-8
Boc-Met-Glu-His-Phe-Pro-Gly-Pro
111491-74-8
C₅₀H₇₅N₉O₁₂S
15761-39-4
1-(tert-butoxycarbonyl)-L-proline
1738-78-9
L-phenylalanine benzyl ester p-toluene-sulfonic acid salt

80714-61-0 Downstream products

14517-44-3
L-methionyl-L-glutamic acid

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