What is the Sodium cyanoborohydride?

Sodium cyanoborohydride is white crystalline powder, while it's Molecular Formula is NaBH3CN. white crystalline powder Sodium Cyanoborohydride is a commonly used as a reagent in the reductive amination of aldehydes and ketones and in the reductive alkylation of amines. It is also used in the synthesis of a novel phenolate-bridged dilanthanum(III) complex of interest as a model for metalloproteins as well as for its importance in basic and applied chemistry.

What is the CAS number for Sodium cyanoborohydride?

The CAS number of Sodium cyanoborohydride is 25895-60-7.

What is Sodium cyanoborohydride (25895-60-7) used for?

Sodium cyanoborohydride (NaBH3CN) is a selective reducing agent used for a variety of chemical reductions, including aldehyde, ketones, acetals, epoxides, oximes, enamines, reductive aminations of aldehydes and ketones, and reductive alkylations of amines and hydrazines. The utility of sodium cyanoborohydride as a reducing agent is greatly enhanced by its stability under acid conditions, and its solubility in aprotic solvents. Sodium cyanoborohydride is a milder and more selective reducing agent than sodium borohydride.Sodium cyanoborohydride is a weaker and more-selective reducing agent than sodium borohydride because of the electron-withdrawing effect of the cyano group. It has the further advantage that it is stable in acid to pH = 3 and can be employed to effect reductions in the presence of functional groups that are sensitive to the more-basic conditions of reduction with sodium borohydride.Aldehydes and ketones are unaffected by sodium cyanoborohydride in neutral solution, but they are readily reduced to the corresponding alcohol at pH=3-4 by way of the protonated carbonyl group. By previous exchange of the hydrogens of the borohydride for deuterium or tritium, by reaction with D2O or tritiated water, an efficient and economical route is available for deuteride or tritiide reduction of aldehydes and ketones.InChI:InChI=1/CH3BN.Na/c2-1-3;/h2H3;/q-1;+1

TAK-385 is , while it's Molecular Formula is C29H27F2N7O5S. Relugolix is a highly selective, oral, nonpeptide GnRH antagonist being investigated as a possible prostate cancer treatment

What is the CAS number for TAK-385?

The CAS number of TAK-385 is 737789-87-6.

What is TAK-385 (737789-87-6) used for?

Relugolix (TAK-385)?is a potent, orally active, nonpeptidic?gonadotropin-releasing hormone (GnRH)?antagonist. It possesses high affinity and potent antagonistic activity for human receptor (binding?IC50=0.33 nM) and monkey receptor (IC50=0.32 nM) compared with TAK-013 (HY-100209). Relugolix is used for the study of sex-hormone-dependent diseases, such as including endometriosis, uterine fibroids and prostate cancer et al.

Relugolix

Basic information

Product Name:Relugolix
CasNo.:737789-87-6
MF:C29H27F2N7O5S
MW:623.63

Physical and Chemical Properties

Purity:99%
Boiling Point:228 °C (decomp)(Solv: ethyl acetate (141-78-6); tetrahydrofuran (109-99-9))
Packing:
Throughput:

Inquiry

Product Details

CasNo： 737789-87-6

MF： C29H27F2N7O5S

Top Purity 99% Trustworthy Manufacturer Supply Relugolix 737789-87-6 with Reasonable Price

Molecular Formula:C29H27F2N7O5S
Molecular Weight:623.63
Melting Point:228 °C (decomp)(Solv: ethyl acetate (141-78-6); tetrahydrofuran (109-99-9))
PKA:13.17±0.70(Predicted)
PSA：182.86000
Density:1.442±0.06 g/cm3(Predicted)
LogP:3.69890

Relugolix (Cas 737789-87-6) Usage

Description	Relugolix, is a gonadotropin-releasing hormone antagonist (GnRH receptor antagonist) medication that is used in the treatment of prostate cancer in men and uterine fibroids in women.
Use	Relugolix is a GnRH receptor antagonist primarily used in medicine to treat conditions such as prostate cancer, endometriosis, and uterine fibroids by suppressing the production of sex hormones.

737789-87-6 Relevant articles

Synthetic method of Relugolix

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Preparation method of Relugolix

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737789-87-6 Process route

: 697-73-4
2,6-difluorobenzyl chloride

: 737789-87-6
TAK-385

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 100 °C 2.1: potassium carbonate / 3 h / 60 °C 3.1: tetrahydrofuran / 5 h / 70 °C 4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux 5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C 6.1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 20 °C 7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C 7.2: 4.5 h / 50 °C With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetonitrile;

Yield

Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 100 °C

2.1: potassium carbonate / 3 h / 60 °C

3.1: tetrahydrofuran / 5 h / 70 °C

4.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

6.1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

7.2: 4.5 h / 50 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetonitrile;

: C₃₁H₃₃F₂N₇O₆S

: 737789-87-6
TAK-385